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Image Search Results
Journal: Biomedicines
Article Title: Effect of Serping1 siRNA Injection on Dopaminergic Cell Reduction in an MPTP-Induced Parkinson’s Disease Mouse Model
doi: 10.3390/biomedicines14030569
Figure Lengend Snippet: Changes in cyclooxygenase-2 (COX2) and inducible nitric oxide synthase (iNOS) levels in the striatum by injecting Serping1 siRNA. ( A ) Immunoblot results of COX2 and iNOS in the striatum of C, NC, SER1, and NAC groups. ( B ) The immunoblot of COX2 and iNOS is shown in a graph. COX2 and iNOS levels increased significantly in the NC group. However, COX2 levels decreased significantly in the SER1 and NAC groups, and iNOS levels also decreased in the SER1 and NAC groups; (COX2, n = 3, F(3,8) = 14.270, ANOVA = 0.001; iNOS, n = 3, F(3,8) = 4.366, ANOVA = 0.042) means ± standard errors, * p < 0.05, ** p < 0.005, # p = 0.067.
Article Snippet: Then, the membranes were incubated with primary antibodies: anti-TH (1:2000; Santa Cruz Biotechnology, Dallas, TX, USA), anti- Serping1 (1:2000; Cloud clone Corp., Katy, TX, USA), anti-β-actin (1:5000; Santa Cruz Biotechnology), anti-pSer129-α-syn (1:1000; FUJIFILM Wako Pure Chemical Corp., Osaka, Japan),
Techniques: Western Blot